I just downloaded Google Chrome, and will be updating this post as I use it. I will be comparing it primarily to Firefox 3.
In terms of loading speed, it seems to be roughly the same as Firefox 3, maybe a little faster. However, comapred to the huge speed advantage both of them have over IE, it is not very noticeable.
Like Firefox, the application is only 32 bit. I would have preferred to have a native x64 version, but this is not critical. The browser does seem to be very heavily optimized for multi threading, as it opens multiple threads in task manager, compared to Firefox’s 1.
In terms of the user interface, the much vaunted monobar thing is exactly the same as the one that comes with Firefox 3, although I prefer the drop down for recent sites in FF. One the other hand, the list of most visited sited is somewhat nice, although the functionality is replicated by the bookmark bar in FF. You can definitely tell that they took from the design of Firefox in many places, such as the bar that pops up asking to remember your password.
More to come.

